Cadmium Concentrations in Blood and Seminal Plasma: Correlations with Sperm Number and Motility in Three Male Populations (Infertility Patients, Artificial Insemination Donors, and Unselected Volunteers)

摘要: To investigate a possible common environmental exposure that may partially explain the observed decrease in human semen quality, we correlated seminal plasma and blood cadmium levels with sperm concentration motility. We studied three separate populations: group 1, infertility patients (Long Island, NY, USA); 2, artificial insemination donors (AID) (Rochester, 3, general population volunteers USA). Information about confounding factors was collected by questionnaire. Seminal did not correlate (Spearman correlation, n = 91, r −0.092, P 0.386, NS). Both were significantly higher among than other subjects (for example, median 0.282 µg/L versus 0.091 AID 0.092 volunteers; Kruskal-Wallis test, < 0.001). The percentage of motile inversely (r −0.201, 0.036 −189, 0.05, respectively), but two groups. Age (among patients) only positive confounder correlating cadmium. validate our findings an animal model, chronically exposed adolescent male Wistar rats to low-moderate drinking water. Though otherwise healthy, exhibited decreases epididymal count motility associated dose time exposure. Our rat study results are consistent hypothesis exposures contribute reduced