Exposure to bisphenol A and behavior in school-age children.

摘要: Abstract Introduction Bisphenol A (BPA) exposure has been shown to affect human brain neurodevelopment and behavior. Objective We aimed investigate whether environmental BPA in children was associated with their childhood Methods Urinary concentrations behavioral characteristics were assessed 300 belonging the INMA “Environment Childhood” Granada birth cohort follow-up at 9–11 years of age. quantified urine using liquid chromatography-tandem mass spectrometry (LC–MS–MS), child behavior reported by parents Child Behavior Checklist (CBCL/6–18) under supervision a psychologist. The association between CBCL standardized scores analyzed linear regression models, adjusted for important covariates. Results Median (P25, P75) concentration 4.76 (2.77, 9.03) μg/L. Mean (±SD) externalizing internalizing 56.35 (±8.06) 51.36 (±9.22), respectively. In multivariate analyses, maternal characteristics, higher worse on all scales. Children 4th quartile had more somatic complaints ( β  = 2.35; 95% CI: 0.25, 4.46) social  = 1.71; 0.19, 3.22) thought problems  = 2.58; 0.66, 4.51) comparison those 1st quartile. values 3rd also showed greater  = 1.94; 0.43, 3.45). Conclusions Our results suggest that may children's Although further investigations are required, preventive measures should be undertaken reduce inadvertent BPA.