The epidemiologic approach to pharmacogenomics.

摘要: The epidemiologic approach enables the systematic evaluation of potential improvements in safety and efficacy drug treatment which might result from targeting on basis genomic information. main designs are randomized control trial, cohort study, case-control derivatives these proposed for investigating gene-environment interactions. However, no one design is ideal every situation, methodological issues, notably selection bias, information confounding chance, all play a part determining study best given situation. There also need to employ range different establish portfolio evidence about specific gene-drug In view complexity interactions, pooling data across studies likely be needed order have adequate statistical power test hypotheses. We suggest that there may opportunities (i) exploit samples trials already completed investigate possible interactions; (ii) consider use case-only nested within controlled as means reducing genotyping costs when dichotomous outcomes being investigated; (iii) make population-based disease registries can linked with tissue samples, death records, gene-treatment interactions survival.