Midazolam: effects on amnesia and anxiety in children.

摘要: Background The minimum time interval between administration of oral midazolam and separation children from their parents that ensures good anterograde amnesia has not been previously determined. This is particular importance in a busy operating room setting where schedule delays secondary to may be tolerated. Methods Children (n = 113) undergoing general anesthesia surgery completed preoperative baseline memory testing using validated series picture cards were randomly assigned one three groups or control group. Exactly, 5, 10, 20 min after receiving (0.5 mg/kg) 15 placebo, administered second test used pictures. Anxiety was assessed during induction with use anxiety measurement tool. Postoperatively, recall recognition for seen postintervention assessed. Results pictures presented patients drug (anterograde amnesia) showed significant group differences (P 0.0001), impaired the 10- 0.004) 20-min 0.0001). Similarly, 5- 0.0008), 0.0001) groups. Significant anxiolytic effects observed as early +/- 4 0.02). Conclusions Midazolam orally produces when given 10 before surgical procedure.