Atypical antipsychotics and diabetic ketoacidosis: a review

摘要: Atypical antipsychotics have been linked to weight gain and type 2 diabetes, but are also associated with diabetic ketoacidosis (DKA), which can occur more acutely in the absence of gain. Our aim was review current case reports DKA context atypical antipsychotic treatment better understand (a) scope problem, (b) its relationship different agents, (c) risk factors, (d) long-term outcome, (e) putative mechanisms action. Searches PubMed/Medline, as well University Toronto’s Scholar Portal, were performed for all relevant articles/abstracts English. Sixty reports, yielding 69 cases, affirm that is a rare serious almost antipsychotics; however, liability seems vary between at least partially mirroring Mean age onset 36.9 years (range 12–80), 68 % cases occurring males, 41 % individuals African American or Caribbean descent. Over one third present either no loss, 61 % these require ongoing glycemic control. Death occurred 7.25 % cases. While underlying not understood, antipsychotic-related soon after Although rare, clinicians must remain vigilant given acute potential lethality.