3‐Methyl‐3‐sulfanylhexan‐1‐ol as a Major Descriptor for the Human Axilla‐Sweat Odour Profile

摘要: This study sets out to redress the lack of knowledge in area volatile sulfur compounds (VSCs) axillary sweat malodour. Sterile odourless underarm (500 ml) was collected from 30 male volunteers after excessive sweating. Five strains bacteria, Corynebacterium tuberculostearicum, minutissimum, Staphylococcus epidermidis, haemolyticus, and Bacillus licheniformis, were isolated characterised for their ability generate an authentic odour material collected. As expected, all five bacterial produced strong odours. Surprisingly, extensive olfactive evaluation, strain haemolyticus most sulfury character. then chosen as change agent 500 ml After incubation, 500-ml sample further processed GC-olfactometry (GC-O), GC/MS analysis. GC-O extract free organic acids provided three zones interest. The first chicken-sulfury, second zone onion-like, third sweat, clary sage-like. From zone, a new impact molecule, (R)- or (S)-3-methyl-3-sulfanylhexan-1-ol, identified by GC/MS, MD-GC, GC AED (atomic emission detector). (S)-3-methyl-3-sulfanylhexan-1-ol sniff-evaluated upon elution chiral column described onion-like; its opposite enantiomer, (R)-3-methyl-3-sulfanylhexan-1-ol, fruity grapefruit-like. (S)-form found be major enantiomer (75%).