Activity and pharmacokinetics of a new oral dosage form of soluble ibuprofen.

摘要: The pharmacokinetics and the relative bioavailability of a soluble granular form (sachets) pharmaceutical formulation containing ibuprofen (CAS 15687-27-1) 1-arginine were investigated in healthy volunteers. Two dosage forms evaluated, 200 400 mg, comparison with commercial equivalents (tablets). After oral administration both forms, quicker absorption significantly higher plasma first hour following treatment than after tablets observed. mean values peak concentration (microgram/ml) 26.1 56.4 mg sachets respectively vs. 16.3 43.0 tablets. time 16.9 24.4 min 90.0 63.7 shortening increase concentrations did not involve drug elimination nor cause any changes (mean indexes 0.98 for 1.02 one). analgesic activity was compared that patients osteo-articular pain, according to single dose, double-blind cross-over balanced design. results showed is able determine an effect