Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.
作者： HERMANN NAWRATH
DOI: 10.1038/262509B0
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摘要: CYCLIC AMP and cyclic GMP have been suggested to play opposing regulatory roles in several biological systems1. Supporting evidence for the yin yang hypothesis of regulation has obtained sympathetic ganglia2,3 pyramidal neurones rat cerebral cortex4. In mammalian heart, role mediating positive inotropic response catecholamines was advanced by observation that effect preceded an increase levels5. On other hand, levels were found be increased after cholinergic stimulation6. frog, oscillations AMP7 changes GMP8 during cardiac cycle reported. The importance effects confirmed dibutyryl derivative exerted a cat papillary muscles9 isolated perfused hearts from rabbits, rats guinea pigs10. I now report direct negative 8-Br-cyclic on force contraction (Fc) auricles muscles cats.
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