Risk factors and therapeutic significance of inguinal lymph node metastasis in advanced lower rectal cancer

摘要: This study aimed to clarify predictors and therapeutic significance of inguinal lymph node metastasis (ILNM) in patients with rectal cancer. Patients adenocarcinoma invading the anal canal who underwent curative surgery between 2003 2019 were retrospectively reviewed. Synchronous metachronous (LN) collectively defined as final nodal (f-LNM). Factors associated f-LNM analyzed. Moreover, “modified value index,” by multiplication frequency 5-year overall survival rate for received treatment f-LNM, was calculated each LN area. A total 145 enrolled (16 f-ILNM). To predict f-ILNM, cutoff (ILN) diameter 8.5 mm gave an area under curve 0.889. Dentate line involvement (odds ratio 33.4) ILN larger than 8 mm 11.9) independently f-ILNM. The modified indices inguinal, lateral pelvic, mesorectal LNs entire population 6.1, 8.2, 20.3 points, respectively. In dentate invasion cancer, index increased 11.7 points. > 8 mm, further 21.1 > 8 mm predicted development ILNM cancer canal. Treatment should be considered above given significant outcomes.