Recombinant secretory immunoglobulin A in passive immunotherapy: linking immunology and biotechnology.

摘要: The use of monoclonal antibodies has become routine in the research and diagnostic laboratories, but potential antibody molecules public health medical applications is still far from its maximum. Most infections begin at mucosal surfaces, this certainly not only a stroke good fortune if mother's milk serves as natural delivery vehicle for protecting gastrointestinal tract nursing infants. Mammary gland or other mucous secretions containing numerous specificities provide an efficient mean to immediately protect surface against pathogens, which have never been encountered by host. From perspective, topical passive immunization surfaces with can block entry transmission bacteria, viruses, fungi parasites that infect humans, thus defeat some key immune evasion strategies designed many pathogens. chief on most secretory immunoglobulin A (SIgA), polypeptide complex comprising dimeric IgA, connecting J chain, component. molecular stability, tetravalency, strong anti-inflammatory properties make SIgA particularly well suited fulfill function protective immunity when applied exogenously surfaces. review will give overview basic concepts underlying immunity, present mechanisms whereby prevents infections, cover last advances topic recombinant production, examine how structure-function relationship help designing novel immunotherapy.