Impact of Substance Use Disorder on Midterm Mortality After Valve Surgery for Endocarditis

摘要: Background Fueled by the burgeoning opioid epidemic, valve surgeries for substance use disorder-related infective endocarditis (SUD-IE) are increasing. The impact of disorder on postvalve replacement morbidity needs further investigation. Methods We queried Society Thoracic Surgeons Adult Cardiac Surgery Database all at Tufts Medical Center (2002-2016) and collected demographic disease-related data, including timing mortality subclassified as short-term ( 5 years). Patients with documentation illicit drug before operation were considered to have SUD-IE. Deaths confirmed through review medical record matching Massachusetts Vital Statistics Database. performed univariate multivariate proportional hazard regressions examining in people who received a replacement. Results In cohort 228 patients, 80 (35%) had Eight-six (38%) died, overall was higher SUD-IE compared non–SUD-IE (48% vs 32%, P = .025). associated risk (adjusted ratio, 2.41; 95% confidence interval, 1.38-4.20; .002). Although difference between or extended-term was not significant, increased frequency midterm (53% 31%, .003). Conclusions Our data reflect high rates surgery tertiary care center. postoperative period is vulnerable worthy