Hitchhiker's guide to the red cell storage galaxy: Omics technologies and the quality issue.

摘要: Abstract Red blood cell storage in the bank makes millions of units available for transfusion to civilian and military recipients every year. From glass bottles plastic bags, from anticoagulants complex additives, whole leukocyte filtered packed red cells: huge strides have been made field component processing during last century. Still, refrigerated preservation cells under conditions results progressive accumulation a wide series biochemical morphological changes stored erythrocytes, collectively referred as lesion(s). Approximately ten years ago, retrospective clinical evidence had suggested that such lesion(s) may be clinically relevant mediate some untoward transfusion-related effects observed especially categories at risk ( e.g. massively or chronically transfused recipients). Since then, randomized trials failed prospectively detect any signal related duration increased morbidity mortality several recipients, limits statistical power these studies. While good part community has immediately adopted take-home message “if it isn’t broken, don’t fix it” i.e. no change standard practice should pursued), decision makers further questioning whether there room improvements this field. Provocatively, we argue consensus yet unanimously reached on what quality marker lesion safety/efficacy. In other words, if is true “you can’t manage you measure”, then future advancements medicine will necessarily rely state art analytical omics technologies well-defined parameters. Heavily borrowing Douglas Adam's imaginary repertoire world famous “Hitchhiker's guide galaxy”, briefly summarize how principles intergalactic hitchhikers indeed apply inform navigation through universe quality, safety efficacy.