Current status of genome editing in vector mosquitoes: A review.

摘要: Mosquitoes pose a major threat to human health as they spread many deadly diseases like malaria, dengue, chikungunya, filariasis, Japanese encephalitis and Zika. Identification use of novel molecular tools are essential combat the vector borne diseases. Genome editing have been used for precise alterations gene interest producing desirable trait in mosquitoes. Deletion functional genes or insertion toxic mosquitoes will produce either knock-out knock-in mutants that check vector-borne Presently, three types genome viz., zinc finger nuclease (ZFN), transcription activator-like effector nucleases (TALEN) clustered regulatory interspaced short palindromic repeats (CRISPR) CRISPR associated protein 9 (Cas9) widely genomes diverse organisms. These also applied control A few studies carried out on by more need be performed with utilization recently invented CRISPR/Cas9 The high specificity flexibility system may offer possibilities important In this review, we present current status research discuss future applications mosquito vectorborne