Proteomics in the Systems-Level Study of the Metabolic Syndrome

摘要: Proteomics has come a long way from the initial qualitative analysis of proteins present in given sample to large-scale characterization proteomes, their interactions and dynamic behaviour time space. Originally enabled by breakthroughs protein separation visualization (by two-dimensional gels electrophoresis) identification mass spectrometry), discipline now encompasses large body peptide separation, labelling, detection sequencing tools supported stable-isotope- label-free techniques computational data processing for quantitative proteomics. The key functional importance investigate complement driven study proteomes numerous physiological pathological conditions. been mainly applied discovering novel biomarkers disease, evidenced fact that most clinical tests today measure blood. Moreover, understanding proteome helps health disease states understand mechanisms action specific molecules, e.g., nutrients or drugs. Here, we briefly recapitulate proteomic technologies cover evolution today’s future cutting-edge platforms. Then review discuss applications metabolic syndrome.