Longitudinal Postnatal Weight and Insulin-like Growth Factor I Measurements in the Prediction of Retinopathy of Prematurity

摘要: Objective To investigate whether postnatal growth and development influence retinopathy of prematurity (ROP) may be included in screening for ROP. Design We developed an algorithm to predict individual infants the risk later ROP requiring treatment based on longitudinal systemic factors insulin-like factor I (IGF-I) level, IGF binding protein 3 weight gain. 79 preterm considered at by standard criteria (gestational age, 23.6-31.7 weeks) a study measuring gain serum IGF-I levels weekly from birth until discharge hospital. monitored deviations reference models level (preterm children who no or minimal ROP) detect indications treatable Early Treatment Retinopathy Prematurity criteria. Results This monitoring method detected 6 (100%) this cohort required with warning signal least 5 weeks before onset stage The majority (61/73 infants) were also correctly identified. Conclusions Monitoring weight, substantially enhances clinician's ability identify patients will require