Solid and hematologic malignancies in 60 patients with systemic mast cell disease.

摘要: Although the association of malignancies and systemic mast cell disease (SMCD) is well established, nature this relationship poorly understood. The observation 19 in 17 60 patients with SMCD raised several questions regarding chronological onset malignancies, whether these are at increased risk for developing malignancy, distribution solid vs hematologic indicates a between particular tumor. following were observed: eight tumors, seven acute nonlymphocytic leukemias, three malignant lymphomas, one refractory anemia excess blasts transformation. majority (13/17) found to have before, or within 12 months of, diagnosis. Statistical analysis suggested that not subsequent diagnosis SMCD. varied types observed indicated random distribution, contrast appeared primarily affect myeloid cells.