Role of HDAC6 inhibition in sepsis-induced acute respiratory distress syndrome (Review).

摘要: Acute respiratory distress syndrome (ARDS) induced by sepsis contributes remarkably to the high mortality rate observed in intensive care units, largely due a lack of effective drug therapies. Histone deacetylase 6 (HDAC6) is class-IIb that modulates non-nuclear protein functions via deacetylation and ubiquitination. Importantly, HDAC6 has been shown exert anti-cancer, anti-neurodegeneration, immunological effects, several inhibitors have now entered clinical trials. It also recently modulate inflammation, inhibition demonstrated markedly suppress experimental sepsis. The present review summarizes role sepsis-induced inflammation endothelial barrier dysfunction recent years. proposed predominantly ameliorates ARDS directly attenuating which innate adaptive immunity, transcription pro-inflammatory genes, protects function. against ARDS, thereby making promising therapeutic target. However, HDAC may be associated with adverse effects on embryo sac oocyte, necessitating further studies.