Nematode Infection Enhances Survival of Activated T Cells by Modulating Accessory Cell Function
作者： Timothy D. G. Lee , Robert S. Liwski
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摘要: The type of immune response generated following exposure to Ag depends on a variety factors, including the nature Ag, adjuvant used, site antigenic entry, and status host. We have previously shown that infection rodents with Nippostrongylus brasiliensis (Nb) shifts development 1 allo-specific responses toward 2 immunity, suggesting nematode modulation T cell activation. In this report we explore immunomodulatory effects Nb found spleen cells from Nb-infected mice exhibited dramatically increased proliferation in Con A anti-CD3. This hyperproliferation could be transferred vitro naive splenocytes by coculture mitomycin C-treated animals. transfer was mediated non-T accessory supernatants derived A-activated cells, involvement soluble factor secreted cells. high levels IL-6, anti-IL-6 treatment abrogated supernatant-induced hyperproliferation, thus confirming IL-6 mediating effect. Further, were more resistant activation-induced death (AICD) mitogenic stimulation. Reduced AICD also transferable dependent. Thus, part due enhanced activated survival. These phenomena may contribute powerful polyclonal activation immunity caused infection.
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