Pregnancy registries in epilepsy.

摘要: The risk of major malformations in the offspring mothers with epilepsy receiving antiepileptic drugs is 4--8% compared to 2--4% general population. Risk factors include daily dose and polytherapy. Selected have been found be associated a higher specific (congenital heart defects cleft palate phenytoin barbiturates; neural tube valproate carbamazepine). Although some these findings are unquestionable, several questions still unsolved, depending characteristics target populations, small samples patients, design limiting published reports. In last decade, pregnancy registries activated by collaborative groups physicians Europe (EURAP), North America (NAREP), Australia India (the latter two recently merged into EURAP), enroll large number exposed women monitored prospectively standardized methods, three pharmaceutical companies marketing lamotrigine, gabapentin vigabatrin, as part their post-marketing surveillance. Even though structure populations should theoretically result identification sufficient different examined for occurrence any type severity, implementation common database information from existing may provide valuable shorter time period. differences between limit possibility pool data, gradual development collaboration highly desirable discuss list issues assess what extent how data could organized.