Biochemical Considerations in the Design of Radiopharmaceuticals

摘要: The goal of radiopharmaceutical chemistry is to design and develop radiotracers targeted an organ or function whose activity kinetics in tissue can be detected externally by a gamma positron device. Three years ago, Eckelman Reba (1) divided radiopharmaceuticals into the general categories specific non-specific agents. are tracers that follow biochemical pathway involved particular interaction, for example metabolic substrates, drugs analogs, antibodies, Non-specific include radiolabeled liposomes, cells, microspheres, perfusion agents, inert gases, ethers, alcohols thallium-201. development both types important. In case myocardial imaging agent will enable differentiation various stages ischemia infarction as essential tracer reflect metabolism since functions change with injury.