Dietary fatty acids on aortic root calcification in mice with metabolic syndrome
作者： Maria C Naranjo , Beatriz Bermudez , Indara Garcia , Sergio Lopez , Rocio Abia
DOI: 10.1039/C7FO00143F
关键词:
摘要: Metabolic syndrome (MetS) is associated with obesity, dyslipidemia, type 2 diabetes, and chronic low-grade inflammation. The aim of this study was to determine the role high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on vascular calcification by modulation RANKL/RANK/OPG system aortic roots Lepob/obLDLR−/− mice. Animals fed HFLCD-SFAs had increased weight a greater atheroma plaque size, calcification, RANKL/CATHK expression root than mice MUFA-enriched diets, an increasing OPG latter. Our demonstrates that compared dietary SFAs, from olive oil protect against atherosclerosis interfering via setting MetS. These findings open opportunities for developing novel nutritional strategies as most important source (notably oleic acid) prevent cardiovascular complications
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