Variables associated with the risk of colorectal adenomas in asymptomatic patients with a family history of colorectal cancer.

摘要: The results of screening individuals referred to the Family Cancer Clinic at St Mark's Hospital from 1986 are presented. Colonoscopy was performed in 644 asymptomatic (from 436 families) with a family history colorectal cancer. Sixty nine (15.8%) families fulfilled Amsterdam criteria for hereditary non-polyposis cancer syndromes (HNPCC). Seven cases were diagnosed an average age 49 years; six Dukes's stage A and one C, four subjects families. One hundred forty (22.4%) had or more adenomas. prevalence adenomas 34 127 (26.8%) compared 110 517 (21.3%) those other families; sex adjusted odds ratio (OR) 1.76 (p = 0.02). Factors influencing screened evaluated. Multivariate analysis showed that independent variables significantly related risk were: 2 v 1) relatives affected by either 0.0006). latter variable highly predictive probability finding adenoma colonoscopy than two generations only 0.056). OR having increased age, about twofold each decade, twice as high men women, relative generation Six seven patients 46 144 (31.9%) lesions proximal splenic flexure only. proportion 47.1% 27.3% others (p=0.03). These findings support view rather sigmoidoscopy is method choice groups.