The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer

摘要: Gastric cancer (GC) is one of the most common types across world. GC carcinogenesis demonstrates a multi-step progression with accumulation genetic and epigenetic changes. The changes on gene expression, without any change deoxyribonucleic acid (DNA) sequencing, are named as “epigenetic”. DNA methylation commonly studied modification in mammalians. Hypermethylation observed CpG (—C— phosphate—G—) islands In GC, promoter regions genes. This significant mechanism that causes functional losses tumor suppressor gastric cancer, hypermethylation seen many Helicobacter pylori (H. pylori) type spiral-shaped Gram-negative bacteria. It infects approximately half world’s population. H. an important etiological factor human beings. Chronic infection associated sequences different paper provides review current literature relationship between GC. J Microbiol Infect Dis 2015;5(4): 187-190 Key words: pylori, hypermethylation.