Durchbruchschmerzen und kurz wirksame Opioide

摘要: Conventional opioid therapy consists of the regular administration extended-release opioids following fixed time intervals and, as needed, supplemental use an immediate-release formulation. For patient needs such rescue medication, recent studies distinguished different scenarios, inadequate daily dose or interval (end-of-dose failure) from so-called breakthrough pain where attacks can suddenly occur either spontaneously (idiopathic pain) due to certain provocations (incident despite optimal adjustment. In line with this course, a fast and short-lasting elevation plasma concentration seems be reasonable. Although in European survey majority cancer patients were sufficiently treated opioids, currently running clinical trials examine whether application transmucosal intranasal fentanyl their known reduced maximum concentrations show possible advantage comparison opioids. these intensity number episodes significantly fentanyl; however, magnitude effects does not convincingly appear clinically relevant. Among other reasons may related fact that those who would perhaps benefit treatment have yet been identified.