13,13A-Didehydroberbine derivatives

摘要: The present invention provides a cholesterol biosynthesis inhibitor which specifically inhibits the sterol 14-reductase is involved in distal pathway of biosynthesis, compound formula (1) below and use an extract or for treating hypercholesterolaemia hyperlipidaemia. comprises obtained by extracting Corydalis Turtschaninowii Besser with solvent, organic layers partitioning from solvent. contains 7,8,13,13α-tetrahydrocoridaline its derivative, as active ingredients, enzyme biosynthesis. R1 R2 may be same different each other, represent hydroxy group alkoxy having 1 to 4 carbon atoms both methylenedioxy group; R3 represents hydrogen atom; R4 R5 group, hydroxyethylamino atoms; R6 atom, alkyl 8 atoms, alkenyl 3 cycloalkylalkyl 7 holoalkyl ethoxycarbonyl ethoxycarbonylmethyl hydroxycarbonylmethyl 1-ethoxycarbonylethyl 2-valerolactonyl group.