Water uptake and drug release behaviour of methyl methacrylateco-itaconic acid [P(MMA/IA)] hydrogels cross-linked with methylene bis-acrylamide
作者： A. Hussain , S.H. Khalid , M.I. Qadir , A. Massud , M. Ali
DOI: 10.1016/S1773-2247(11)50034-6
关键词:
摘要: Hydrogels are water-swollen, cross-linked polymeric structures. The objective of this study was to synthesize a new pH-sensitive copolymer, which shows no water uptake at lower pH values but maximum higher values. Methyl methacrylate-co-itaconic acid [P(MMA/ IA)] hydrogels with methylene bis-acrylamide were synthesized. To determine the effect monomeric composition, copolymers prepared different proportions methyl methacrylate and itaconic i.e. 100:0, 90:10, 85:15, 80:20 75:25 keeping degree cross-linking constant 0.30 mol %. It concluded from that MMA/IA (x = 0.3 mol %) polymer fulfilled our objective. seems suitable for delivering drug above pH 6.
elsevier.com
sci-hub.se 
researchgate.net 参考文章(20)
R. A. Couch, B. A. Burnside, R.-K. Chang, Xiaodi Guo, Fast-dissolving tablets Pharmaceutical technology. ,vol. 24, pp. 52- 58 ,(2000)
Edith Mathiowitz, Encyclopedia of Controlled Drug Delivery ,(1999)
Richard W. Korsmeyer, Robert Gurny, Eric Doelker, Pierre Buri, Nikolaos A. Peppas, Mechanisms of solute release from porous hydrophilic polymers International Journal of Pharmaceutics. ,vol. 15, pp. 25- 35 ,(1983) , 10.1016/0378-5173(83)90064-9
Waleed S.W. Shalaby, William E. Blevins, Kinam Park, In vitro and in vivo studies of enzyme-digestible hydrogels for oral drug delivery Journal of Controlled Release. ,vol. 19, pp. 131- 144 ,(1992) , 10.1016/0168-3659(92)90071-X
Farid A Dorkoosh, J.C Verhoef, G Borchard, M Rafiee-Tehrani, Hans E Junginger, Development and characterization of a novel peroral peptide drug delivery system Journal of Controlled Release. ,vol. 71, pp. 307- 318 ,(2001) , 10.1016/S0168-3659(01)00232-2
O. WICHTERLE, D. LÍM, Hydrophilic Gels for Biological Use Nature. ,vol. 185, pp. 117- 118 ,(1960) , 10.1038/185117A0
Waleed S.W. Shalaby, William E. Blevins, Kinam Park, Use of ultrasound imaging and fluoroscopic imaging to study gastric retention of enzyme-digestible hydrogels Biomaterials. ,vol. 13, pp. 289- 296 ,(1992) , 10.1016/0142-9612(92)90052-P
Joseph Jagur-Grodzinski, Polymeric gels and hydrogels for biomedical and pharmaceutical applications Polymers for Advanced Technologies. ,vol. 21, pp. 27- 47 ,(2010) , 10.1002/PAT.1504
Nazar Mohammad Ranjha, Jahanzeb Mudassir, Naveed Akhtar, Methyl methacrylate-co-itaconic acid (MMA-co-IA) hydrogels for controlled drug delivery Journal of Sol-Gel Science and Technology. ,vol. 47, pp. 23- 30 ,(2008) , 10.1007/S10971-008-1750-Z
S.H. Khalid, M.I. Qadir, A. Massud, M. Ali, M.H. Rasool, Effect of degree of cross-linking on swelling and drug release behaviour of poly(methyl methacrylate-co-itaconic acid) [P(MMA/IA)] hydrogels for site specific drug delivery Journal of Drug Delivery Science and Technology. ,vol. 19, pp. 413- 418 ,(2009) , 10.1016/S1773-2247(09)50085-8