Peroxisomal acyl-CoA synthetases
作者： Paul A. Watkins , Jessica M. Ellis
DOI: 10.1016/J.BBADIS.2012.02.010
关键词:
摘要: Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the side chain steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions proceed. This thioesterification, "activation", reaction, catalyzed by enzymes belonging acyl-CoA synthetase family, is thus central cellular metabolism. However, despite our rather thorough understanding peroxisomal pathways, surprisingly little known about specific synthetases participate in pathways. Of 26 encoded human and mouse genomes, only few have been reported be peroxisomal, including ACSL4, SLC27A2, SLC27A4. In this review, we briefly describe primary pathways which acyl-CoAs participate. Then, examine evidence presence peroxisomes, much was obtained before existence multiple isoenzymes known. Finally, discuss role(s) peroxisome-specific isoforms
core.ac.uk
elsevier.com
sci-hub.se 参考文章(116)
Zhiying Zou, Fumin Tong, Nils J. Færgeman, Claus Børsting, Paul N. Black, Concetta C. DiRusso, Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex Journal of Biological Chemistry. ,vol. 278, pp. 16414- 16422 ,(2003) , 10.1074/JBC.M210557200
Fabian Blobel, Ralf Erdmann, Identification of a Yeast Peroxisomal Member of the Family of AMP‐Binding Proteins FEBS Journal. ,vol. 240, pp. 468- 476 ,(1996) , 10.1111/J.1432-1033.1996.0468H.X
Tetsu Egawa, Katsumi Toda, Yoshihisa Nemoto, Masafumi Ono, Naoaki Akisawa, Toshiji Saibara, Yoshihiro Hayashi, Makoto Hiroi, Hideaki Enzan, Saburo Onishi, Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice. Lipids. ,vol. 38, pp. 519- 523 ,(2003) , 10.1007/S11745-003-1093-X
Y. Cao, A. T. Pearman, G. A. Zimmerman, T. M. McIntyre, S. M. Prescott, Intracellular unesterified arachidonic acid signals apoptosis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 11280- 11285 ,(2000) , 10.1073/PNAS.200367597
Abraham J. K. Koo, Hoo Sun Chung, Yuichi Kobayashi, Gregg A. Howe, Identification of a peroxisomal acyl-activating enzyme involved in the biosynthesis of jasmonic acid in Arabidopsis. Journal of Biological Chemistry. ,vol. 281, pp. 33511- 33520 ,(2006) , 10.1074/JBC.M607854200
R. J. A. Wanders, C. W. T. van Roermund, M. J. A. van Wijland, R. B. H. Schutgens, A. W. Schram, J. M. Tager, H. van den Bosch, C. Schalkwijk, X-linked adrenoleukodystrophy: Identification of the primary defect at the level of a deficient peroxisomal very long chain fatty acyl-CoA synthetase using a newly developed method for the isolation of peroxisomes from skin fibroblasts Journal of Inherited Metabolic Disease. ,vol. 11, pp. 173- 177 ,(1988) , 10.1007/BF01804228
Patricia C. Babbitt, George L. Kenyon, Brian M. Martin, Hugues Charest, Michel Slyvestre, Jeffrey D. Scholten, Kai Hsuan Chang, Po Huang Liang, Debra Dunaway-Mariano, Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases. Biochemistry. ,vol. 31, pp. 5594- 5604 ,(1992) , 10.1021/BI00139A024
Rolf K. Berge, Harald Osmundsen, Asle Aarsland, Mikael Farstad, The existence of separate peroxisomal pools of free coenzyme a and long-chain acyl-CoA in rat liver, demonstrated by a specific high performance liquid chromatography method International Journal of Biochemistry. ,vol. 15, pp. 205- 209 ,(1983) , 10.1016/0020-711X(83)90066-6
Zhenzhen Jia, Zhengtong Pei, Yuanyuan Li, Liumei Wei, Kirby D. Smith, Paul A. Watkins, X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases Molecular Genetics and Metabolism. ,vol. 83, pp. 117- 127 ,(2004) , 10.1016/J.YMGME.2004.06.015
Antonella Pellicoro, Fiona A. J. van den Heuvel, Mariska Geuken, Han Moshage, Peter L. M. Jansen, Klaas Nico Faber, Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport Hepatology. ,vol. 45, pp. 340- 348 ,(2007) , 10.1002/HEP.21528