Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid

摘要: In spite of the effective chronic myeloid leukemia (CML) therapy, a small percentage will fail on therapy and develop acute leukemia-like blast crisis. Understanding underlying biology resistance is probably needed to better blood cancer CML may be an ideal disease model for future that targets mechanisms. Cell-stromal interactions dissection interstitial tissue fluid relatively new source understanding Abdelhay's team have compared proteome bone marrow plasma in imatinib (Gleevec) responders nonresponders. We discuss their findings dysregulated redox Wnt signaling resistance, illustrating how powerful proteomics discovery therapeutic