BINDING PROTEIN-TOXIN CONJUGATES COMPRISING ANTHRACYCLINES, AND USE THEREOF IN IMMUNE-ONCOLOGICAL APPLICATIONS

作者: Grawunder Ulf , Waldmeier Lorenz , Beerli Roger , Pretto Francesca

DOI:

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摘要: The present invention relates to binding protein-toxin conjugates comprising one or more anthracycline toxin moieties, and the use thereof in immunooncological applications.The also claims their combination with an immune checkpoint inhibitor.

参考文章(28)
Ralph M. Myerson, Joseph L. Rabinowitz, Topics in medicinal chemistry John Wiley & Sons. ,(1967)
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) European Journal of Cancer. ,vol. 45, pp. 228- 247 ,(2009) , 10.1016/J.EJCA.2008.10.026
Drew M. Pardoll, The blockade of immune checkpoints in cancer immunotherapy Nature Reviews Cancer. ,vol. 12, pp. 252- 264 ,(2012) , 10.1038/NRC3239
Deborah Finco, Daniel Baltrukonis, Adrienne Clements-Egan, Kathy Delaria, George R. Gunn, John Lowe, Mauricio Maia, Teresa Wong, Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 54, pp. 351- 358 ,(2011) , 10.1016/J.JPBA.2010.08.029
Randy Suryadinata, Gregory Coia, Lisa P. T. Hong, Timothy E. Adams, Charlotte C. Williams, Stewart D. Nuttall, Samuel Baer, Julie Nigro, Mariusz P. Madej, Rebecca M. Nisbet, Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling Organic and Biomolecular Chemistry. ,vol. 12, pp. 2675- 2685 ,(2014) , 10.1039/C3OB42325E
Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer, Jantien Wanders, Richard S. Kaplan, Larry Rubinstein, Jaap Verweij, Martine Van Glabbeke, Allan T. van Oosterom, Michaele C. Christian, Steve G. Gwyther, New Guidelines to Evaluate the Response to Treatment in Solid Tumors JNCI: Journal of the National Cancer Institute. ,vol. 92, pp. 205- 216 ,(2000) , 10.1093/JNCI/92.3.205
Roy Eylenstein, Daniel Weinfurtner, Stefan Härtle, Ralf Strohner, Jark Böttcher, Martin Augustin, Ralf Ostendorp, Stefan Steidl, Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. mAbs. ,vol. 8, pp. 176- 186 ,(2016) , 10.1080/19420862.2015.1099774
Ulf Grawunder, Roger Renzo Beerli, Method of producing an immunoligand/payload conjugate ,(2014)
Frank A Sinicrope, The role of microsatellite instability testing in management of colorectal cancer. Clinical advances in hematology & oncology. ,vol. 14, pp. 476- 479 ,(2016)
Samuele Cazzamalli, Alberto Dal Corso, Dario Neri, Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma Molecular Cancer Therapeutics. ,vol. 15, pp. 2926- 2935 ,(2016) , 10.1158/1535-7163.MCT-16-0283