Molecular mechanisms of reactive oxygen species production: Role of activator protein-1 mediated transcription ofgp91phox, a subunit of the superoxide anion producing phagocyte NADPH oxidase
作者： David John Samuelson
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摘要: 12 L BACKGROUND INFORMATION 14 Reactive oxygen species as initiators and promoters of cancer the multi-stage model carcinogenesis 15 Cellular sources reactive regulation oxidative state 19 Phagocytes: a source initiating, promoting, progressing 21 The gp91phox NADPH oxidase subunit is primary 23 function other components Expression 24 5' regulatory region (promoter) gene 27 tumor promoting phorbol ester, 12-0-TetradecanoyIphorboN 13acetate 32 12-0-Tetradecanoylphorbol-13acetate promotion hematopoietic cell differentiation Protein Kinase C 36 12-0-Tetradecanoylphorbol-13-acetate Activator Protein-1 39 complex activity 41 Involvement in phagocytic 46 Statement problems specific aims 48
openrepository.com参考文章(187)
D Frey, M Machler, R Seger, W Schmid, SH Orkin, Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. Blood. ,vol. 71, pp. 252- 255 ,(1988) , 10.1182/BLOOD.V71.1.252.BLOODJOURNAL711252
Tokuhara M, Matsui M, Ishizaki R, Konuma Y, Nomura N, Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene. ,vol. 5, pp. 249- 255 ,(1990)
Filiberto Cimino, Franca Esposito, Rosario Ammendola, Tommaso Russo, Gene regulation by reactive oxygen species. Current Topics in Cellular Regulation. ,vol. 35, pp. 123- 148 ,(1997) , 10.1016/S0070-2137(97)80005-2
Yen C. Chong, Amy M. Fulton, Leslie A. Paul, Gloria H. Heppner, Macrophage-mediated induction of DNA strand breaks in target tumor cells. Cancer Research. ,vol. 49, pp. 6652- 6657 ,(1989)
Francke U, Distèche C, Pagon Ra, de Martinville B, Pearson Pl, Ochs Hd, van Ommen Gj, Hofker Mh, Lindgren, Giacalone J, Minor Xp21 chromosome deletion in a male associated with expression of duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome American Journal of Human Genetics. ,vol. 37, pp. 250- 267 ,(1985)
Jamel El Benna, La Rosa P. Faust, Jennifer L. Johnson, Bernard M. Babior, Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase. Journal of Biological Chemistry. ,vol. 271, pp. 6374- 6378 ,(1996) , 10.1074/JBC.271.11.6374
Lawrence J. Marnett, Chuan Ji, Modulation of Oxidant Formation in Mouse Skin in Vivo by Tumor-promoting Phorbol Esters Cancer Research. ,vol. 54, ,(1994)
P.E. Newburger, Q. Dai, C. Whitney, In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines. Journal of Biological Chemistry. ,vol. 266, pp. 16171- 16177 ,(1991) , 10.1016/S0021-9258(18)98531-5
R N Kolesnick, Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells Journal of Biological Chemistry. ,vol. 264, pp. 7617- 7623 ,(1989) , 10.1016/S0021-9258(18)83279-3
T P Stossel, S A Weitzman, Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis. Journal of Immunology. ,vol. 128, pp. 2770- 2772 ,(1982)