Expressions of tumor necrosis factor-α, its receptor I, II and receptor-associated factor 2 in the porcine corpus luteum during the estrous cycle and early pregnancy

摘要: We examined the gene and protein levels of tumor necrosis factor (TNF)-α, its receptors (types I II, designated TNF-RI TNF-RII, respectively), TNF receptor-associated 2 (TRAF2) morphological features in porcine corpus luteum (CL), on Days 13 17 (Day 0 = last day estrus) estrous cycle or early pregnancy. Gene expression TNF-α, TNF-RI, TNF-RII TRAF2 were unaffected by reproductive status. TNF-α concentration was significantly higher CL Day pregnancy than cycle. The level those cycle, increasing compared with In relation to levels, although there no change during pregnancy, a tendency (P 0.0524) up-regulate as proceeded. decreased luteolysis estrous. There few apoptotic bodies between esrous. number much greater Thus, pathways including protein, known control cell differentiation, tissue renewal apoptosis, might participate maintaining