Discovery of Heterocyclic Phosphonic Acids as Novelampmimics that are Potent and Selective Fructose‐1,6‐Bisphosphatase Inhibitors and Elicit Potent Glucose‐Lowering Effects in Diabetic Animals and Humans

作者: Qun Dang , Mark D. Erion

DOI: 10.1002/9781118219683.CH4

关键词:

摘要:

参考文章(42)
M.R. el-Maghrabi, M. Gidh-Jain, L.R. Austin, S.J. Pilkis, Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of ASP-118 and ASP-121 in catalysis. Journal of Biological Chemistry. ,vol. 268, pp. 9466- 9472 ,(1993) , 10.1016/S0021-9258(18)98373-0
M Gidh-Jain, Y Zhang, P D van Poelje, J Y Liang, S Huang, J Kim, J T Elliott, M D Erion, S J Pilkis, M Raafat el-Maghrabi, The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure. Journal of Biological Chemistry. ,vol. 269, pp. 27732- 27738 ,(1994) , 10.1016/S0021-9258(18)47047-0
G. Perriello, S. Pampanelli, P. Del Sindaco, C. Lalli, M. Ciofetta, E. Volpi, F. Santeusanio, P. Brunetti, G. B. Bolli, Evidence of Increased Systemic Glucose Production and Gluconeogenesis in an Early Stage of NIDDM Diabetes. ,vol. 46, pp. 1010- 1016 ,(1997) , 10.2337/DIAB.46.6.1010
M.S. Shaikh, Amit Mittal, P.V. Bharatam, Design of fructose-2,6-bisphosphatase inhibitors: A novel virtual screening approach Journal of Molecular Graphics and Modelling. ,vol. 26, pp. 900- 906 ,(2008) , 10.1016/J.JMGM.2007.06.004
Qun Dang, Srinivas Rao Kasibhatla, Tao Jiang, Kevin Fan, Yan Liu, Frank Taplin, William Schulz, Daniel K. Cashion, K. Raja Reddy, Paul D. van Poelje, James M. Fujitaki, Scott C. Potter, Mark D. Erion, Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors. Journal of Medicinal Chemistry. ,vol. 51, pp. 4331- 4339 ,(2008) , 10.1021/JM8001235
Paul D. van Poelje, Qun Dang, Mark D. Erion, Fructose-1,6-bisphosphatase as a therapeutic target for type 2 diabetes Drug Discovery Today: Therapeutic Strategies. ,vol. 4, pp. 103- 109 ,(2007) , 10.1016/J.DDSTR.2007.10.003
Mark D. Erion, Srinivas Rao Kasibhatla, Brett C. Bookser, Paul D. van Poelje, M. Rami Reddy, Harry E. Gruber, James R. Appleman, DISCOVERY OF AMP MIMETICS THAT EXHIBIT HIGH INHIBITORY POTENCY AND SPECIFICITY FOR AMP DEAMINASE Journal of the American Chemical Society. ,vol. 121, pp. 308- 319 ,(1999) , 10.1021/JA983153J
Qun Dang, Srinivas Rao Kasibhatla, Wei Xiao, Yan Liu, Jay DaRe, Frank Taplin, K. Raja Reddy, Gerard R. Scarlato, Tony Gibson, Paul D. van Poelje, Scott C. Potter, Mark D. Erion, Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. Journal of Medicinal Chemistry. ,vol. 53, pp. 441- 451 ,(2010) , 10.1021/JM901420X