Regulatory Forum Opinion Piece* The Value of Publishing Negative Scientific Study Data

摘要: Historically it has been easier to publish positive scientific results than negative data not supporting the research hypothesis. This appears be increasing, with fewer studies appearing in literature across many disciplines. Failure recognize value of important implications for toxicology community. Implications include perpetuating fields based upon selective or occasionally erroneous, results. One example is decreased vaccination rates and increased measles infections that can lead childhood mortality following one erroneous study linking adverse effects despite multiple studies. Publication challenges existing paradigms enhances progress by stopping further investment scientifically barren topics, decreases use animals, focuses more fruitful areas. The National Toxicology Program (NTP) publishes both rodent data. Retrospective analysis NTP database provided insights on carcinogenic process gradual acceptance using animals safety article proposes careful publication enhance product assessment, add robustness determinations regulatory decision-making process, should actively encouraged those determining journal editorial policy.