No impact of acute hyperglycaemia on arterial stiffness in the early and late follicular phases of the menstrual cycle in young females.

摘要: NEW FINDINGS • What is the central question of this study? This first study to examine impact acute hyperglycaemia on arterial stiffness across early and late follicular phases menstrual cycle. main finding its importance? Central peripheral were not impacted by hyperglycaemia. indicates that premenopausal women might experience protection against deleterious effects hyperglycaemia, regardless cycle phase. research furthers our understanding interaction between nutrient intake, hormonal fluctuation vascular function in women. ABSTRACT Acute may result transient increases stiffness. However, healthy lacking, phase [early (EF; low oestrogen) (LF; high oestrogen)] vulnerability hyperglycaemia-induced changes unknown. We hypothesized an increase EF would be attenuated LF Seventeen healthy, naturally menstruating [21 ± 1 years age (mean ± SD)] participated three experimental visits. During two visits, phase, was assessed via (arm leg) pulse wave velocity (PWV) before 15, 45, 75 105 min after consuming oral glucose challenge (75 g 300 ml solution). Blood samples taken assess glucose, insulin, oestrogen progesterone concentrations. a third visit participants ingested water as time control for PWV. Despite significant blood insulin (P < 0.001), both arm PWV remained unchanged indicating neither nor had or There small effect leg PWV, where lower (P = 0.04, Cohen's d = 0.39); however, contrast recent results young men, unaffected These suggest from