Principles of Clinical Chronobiology

摘要: If one examines living matter as a function of time under appropriate experimental conditions, on the cellular level, in tissue culture or multicellular organisms, including man, at different levels physiologic organization invariably finds nonrandom variations variables examined (Aschoff and Wever 1976; Bunning 1973; Conroy Mills 1970; Halberg 1959; Haus et al. 1980, 1988; 1980; Reinberg Ghata 1964). Many these time-dependent changes recur regular intervals thus represent rhythms, which are to certain degree predictable time. With use statistical procedures rhythmometry, large proportion variability encountered most series measurements biologic can be shown due multitude rhythms frequency ranges (Halberg 1965 a, b; Panofsky 1961; 1967; 1981; 1961), may superimposed upon each other trends, e. g., aging. Chronobiology is science investigating objectively quantifying mechanisms this structure rhythmic manifestations life 1977).