Exploration Deficits Under Ecological Conditions as a Marker of Apathy in Frontotemporal Dementia

作者: Bénédicte Batrancourt , Karen Lecouturier , Johan Ferrand-Verdejo , Vincent Guillemot , Carole Azuar

DOI: 10.3389/FNEUR.2019.00941

关键词:

摘要: Apathy is one of the six clinical criteria for behavioral variant frontotemporal dementia (bvFTD), and it almost universal in this disease. Although its consequences everyday life are debilitating, underlying mechanisms poorly known, assessment biased by subjectivity care management very limited. In context, we have developed "ECOCAPTURE," a method aimed at providing quantifiable objective signature(s) apathy order to assess identify precise mechanisms. ECOCAPTURE consists observation recording patient's behavior when participant being submitted multiple-phase scenario reproducing brief real-life situation. It performed functional exploration platform transformed into fully furnished waiting room equipped with video sensor-based data acquisition system. This multimodal allowed video-based analyses according predefined categories (exploration behavior, sustained activities or inactivity) actigraphy from 3D accelerometer. The obtained were also correlated behavioral/cognitive tests scales assessing global cognitive efficiency, apathy, disinhibition, frontal syndrome, depression anxiety. Here, bvFTD patients (n = 14) compared healthy participants during first minutes scenario, discovered encouraged explore it. We showed that, context facing new environment, explored then engaged activities. By contrast, mostly inactive eventually place, but more irregular less efficient mode than normal subjects. deficit was disinhibition dysexecutive syndromes. These findings led us discuss presumed responsible (an inability self-initiate actions, integrate reward valuation inhibit involuntary behavior). Altogether, these results pave way simple changes that represents critical step evaluation disease progression efficacy treatment bvFTD.

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