Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas.

摘要: Background: Disruption of the G1/S check point leads to uncontrolled cell growth, resulting in development cancers, Materials and Methods: Cell cycle regulatory molecules were investigated 33 surgically resected hepatocellular carcinoma (HCC) samples from 30 patients by Western blotting. Results. Enhanced expressions cyclin E A detected at frequencies 18/33 26/33 HCCs, respectively, as compared with their neighboring noncancerous tissues. The enhanced expression E, hut not that A, correlated hyperphosphorylation pRb high frequency Ki-67-positive cells. Thus, HCCs probably contain a relatively large number proliferating cancer Conclusions: degree can he used prognostic parameter HCC. In addition, may become molecular target treatment HCCs.