Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use

摘要: Microcapsules comprising a core containing water-soluble salt of medicament and polymer, e.g., the an amine-group carboxyl group sheath water-insoluble film forming ethyl cellulose, method their production administration are disclosed. The microcapsules can be formed by dispersing aqueous solution medicament-polymer in water-immiscible solvent adding another which is non-solvent for collected microcapsules. administered orally to animals exhibit substantially slower release rates more uniform stomach acids than corresponding unencapsulated salts or encapsulated non-polymeric salts.