Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke.
作者： Cameron Rink , Savita Khanna
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摘要: The significance of the hypoxia component stroke injury is highlighted by hypermetabolic brain tissue enriched with arachidonic acid (AA), a 22:6n-3 polyunsaturated fatty acid. In an ischemic environment in which cerebral blood flow arrested, oxygen-starved initiates rapid cleavage AA from membrane phospholipid bilayer. Once free, undergoes both enzyme-independent and enzyme-mediated oxidative metabolism, resulting formation number biologically active metabolites themselves contribute to pathological outcomes. This review intended examine two divergent roles molecular dioxygen as (1) substrate for life-sustaining homeostatic metabolism glucose (2) pathogenic under conditions stroke. Recent developments research concerning supplemental oxygen therapy intervention correct hypoxic are discussed.
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