Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections.

摘要: During infection by picornaviruses, the cellular environment is modified to favour virus replication. This includes modification of specific host proteins, including recently discovered viral proteinase cleavage mRNA decay factor AU-rich binding 1 (AUF1). RNA-binding protein was shown previously act as a restriction during poliovirus, rhinovirus and coxsackievirus infection. these viruses, AUF1 relocalizes cytoplasm cleaved 3C/3CD proteinase. In this study, we demonstrated that replication encephalomyocarditis (EMCV), picornavirus belonging genus Cardiovirus, independent. EMCV infection, relocalized cytoplasm; however, unlike what seen enterovirus infections, not detectable levels, even at late times after suggests does broadly an inhibitor infections but may instead selective targeting members Enterovirus.