Distribution of endotoxin (lipopolysaccharide) in the tissues of lipopolysaccharide-responsive and- -unresponsive mice.

摘要: We examined the distribution of bacterial lipopolysaccharide (LPS) in LPS-responsive (C3H/St) and LPS-unresponsive (C3H/HeJ) mice. The results reported here demonstrate that rates removal an immunological or a toxic dose LPS from circulation are same both strains C3H/St spleens accumulated significantly more than C3H/HeJ after intravenous injection either immunogenic LPS. There was also greater amount associated with cells teased compared to those spleens. After LPS, there lymph nodes, adrenals, lungs, kidneys, heart corresponding tissues. accumulation tissues mice suggests these involved pathophysiological and, ultimately, effects differential two may be reason for decreased responses