Distribution of glutamate receptors of the NMDA subtype in brains of heterozygous and homozygous weaver mutant mice.

摘要: In weaver mice, mutation of an G-protein inwardly rectifying K+ channel leads to a cerebellar developmental anomaly characterized by granule and Purkinje cell loss and, in addition, degeneration dopaminergic neurons. To evaluate other deficits, glutamate receptors sensitive N-methyl-d-aspartate (NMDA) were examined autoradiography with [3H]MK-801 36 brain regions from heterozygous (wv/+) homozygous (wv/wv) mutants, compared wild type (+/+) mice. wv/+ wv/wv mutants labelling decreased cortical regions, septum, hippocampus, subiculum, neostriatum, nucleus accumbens, superior colliculus the granular layer. The reductions binding particularly specific layer but ubiquitous altered NMDA receptor topology was revealed regions. Abnormal signals, or aberrant cellular responses, may underlie widespread reductions, while cortex they could be lacking due massive cells.