Tumor Angiogenesis and Interstitial Hypertension

摘要: Abstract Due to the high permeability of tumor vessels fluids and plasma proteins, microvascular pressure (MVP) is principal driving force for interstitial hypertension in solid tumors; as a result, hydrostatic pressures between space are close equilibrium. Based on these observations, we hypothesized that fluid (IFP) should increase following onset angiogenesis. To this end, relationship IFP neovascularization was determined human colon adenocarcinoma (LS174T) murine carcinoma (MCaIV) implanted transparent dorsal skin fold chamber severe combined immunodeficient mice. Three stages development neovasculature were characterized by intravital microscopy. Stage I tumors avascular, stage II vascular sprouts loops, III, vasculature completely developed blood flow obvious. The measured with micropipettes servo-null system. For both types, 0 mm Hg, increased significantly from one next. further confirm associated vasculature, LS174T spheroids. mean spheroids 0.2 ± 0.3 Hg. In III tumors, compared MVP. MCaIV, MVP comparable IFP; however, higher than IFP. conclusion, results demonstrate avascular have atmospheric neovasculature.