The efficacy of three mycotoxin adsorbents to alleviate aflatoxin B1-induced toxicity in Oreochromis niloticus

摘要: Aflatoxicosis, toxicity of aflatoxin, is great concern in aquaculture. This study was conducted to assess the efficacies three adsorbents, a hydrated sodium calcium aluminosilicates (HSCAS), Saccharomyces cerevisiae (S.C.) and an esterified glucomannan (EGM), against feed contaminated with contained 200 μg/kg (ppb) aflatoxin B1 (AFB1). A total 240 Nile tilapia fingerlings, Oreochromis niloticus (15 ± 2 g), were randomly divided into eight experimental groups (30 fish per group) replicates. Group T1 represented negative control fed on basal diet, T2 positive group diet supplemented ppb AFB1. Groups T3, T4 T5 AFB1-contaminated (200 ppb) 0.5 % HSCAS, 0.25 S.C or EGM, respectively. T6, T7 T8 The reduction AFB1-bioavailability judged by toxin residues musculature throughout beginning at second week exposure. AFB1 reduced survivability, weight gain, average daily gain specific growth rate, evident as early erythrocyte count, hemoglobin content leukocyte count significantly decreased after exposure for 6, 8 10 weeks, Prolonged administration led significant increases serum alanine transaminase, aspartate transaminase creatinine activity, produced decreases plasma proteins, including globulin. immune response assessed agglutinating antibody titer immunization Aeromonas hydrophila vaccine. relative level protection challenged period examination AFB1-exposed fish. Supplementation S.C. EGM improved performance, blood parameters status; addition, these showed when compared AFB1-treated HSCAS effectively toxicity, whereas less efficacious.