Tranexamic Acid Administration is Associated With a Decreased Odds of Prosthetic Joint Infection Following Primary Total Hip and Primary Total Knee Arthroplasty: A National Database Analysis.

摘要: Abstract Background Tranexamic acid (TXA) for the reduction of blood loss in orthopedic surgery is coming into greater adoption. Because TXA administration lowers incidence transfusion and hematoma formation, risk factors infection, we asked whether use might be associated with a lower periprosthetic joint infection (PJI) following surgery. Methods We queried Premier Healthcare database ICD-9 codes corresponding to elective inpatient primary total hip replacement (THR) or knee (TKR) from 2012 2016, on day surgery, PJI during hospital stay within 90 days. performed multilevel multivariable logistic regression (SAS version 9.4. SAS Institute, Cary, NC) determine if other covariates were significant predictor infection. Results Among 914,990 arthroplasty patients, 46.0% received 0.13% developed After adjusting patient hospital-related covariates, was significantly odds days (OR 0.49 [0.69, 0.91]). Conclusion Administration statistically decreased first therefore conclude that play an important role our attempts decrease after arthroplasty. The exact mechanisms ideal dosage by which can contribute such need further study.