Mass spectrometric detection of polypeptides
作者： David Lough , Hubert Köster , G. Scott Higgins , Daniel Little
DOI:
关键词:
摘要: A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on to be identified, as disclosed can used, example, diagnose genetic disease or chromosomal abnormality, predisposition condition, infection by pathogenic organism; heredity. Kits performing processes also are
google.co.uk参考文章(249)
Christian Jurinke, Bernhard Zöllner, Heinz-Hubert Feucht, Dirk van den Boom, Anette Jacob, Susanne Polywka, Rainer Laufs, Hubert Köster, Application of nested PCR and mass spectrometry for DNA-based virus detection: HBV-DNA detected in the majority of isolated anti-HBc positive sera. Genetic Analysis: Biomolecular Engineering. ,vol. 14, pp. 97- 102 ,(1998) , 10.1016/S1050-3862(97)10006-7
Thomas R. Covey, Ronald F. Bonner, Bori I. Shushan, Jack Henion, R. K. Boyd, The determination of protein, oligonucleotide and peptide molecular weights by ion-spray mass spectrometry. Rapid Communications in Mass Spectrometry. ,vol. 2, pp. 249- 256 ,(1988) , 10.1002/RCM.1290021111
Kuang Jen. Wu, Thomas A. Shaler, Christopher H. Becker, Time-of-Flight Mass Spectrometry Of Underivatized Single-Stranded DNA Oligomers by Matrix-Assisted Laser Desorption Analytical Chemistry. ,vol. 66, pp. 1637- 1645 ,(1994) , 10.1021/AC00082A007
Natalia E. Broude, Charles R. Cantor, Hubert Köster, Dong-Jing Fu, Cassandra L. Smith, Efficient preparation of short DNA sequence ladders potentially suitable for MALDI-TOF DNA sequencing Genetic Analysis: Biomolecular Engineering. ,vol. 12, pp. 137- 142 ,(1996) , 10.1016/1050-3862(95)00125-5
Richard L. Hunter, Robert T. McIver, Yunzhi Li, Kai Tang, Daniel P. Little, Hubert Köster, High-Resolution MALDI Fourier Transform Mass Spectrometry of Oligonucleotides Analytical Chemistry. ,vol. 68, pp. 2090- 2096 ,(1996) , 10.1021/AC9601268
Danielle Promé, Catherine Deon, Jean-Claude Promé, Henri Wajcman, Frédéric Galacteros, Yves Blouquit, Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis β77(EF1) His → Tyr, β 80 (EF4) Asn → Ser. Journal of the American Society for Mass Spectrometry. ,vol. 7, pp. 163- 167 ,(1996) , 10.1016/1044-0305(95)00637-0
N.D. Sinha, J. Biernat, J. McManus, H. Köster, Polymer support oligonucleotide synthesis XVIII1.2): use of β-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product Nucleic Acids Research. ,vol. 12, pp. 4539- 4557 ,(1984) , 10.1093/NAR/12.11.4539
G. Horst, H. Koster, A FILTRATION METHOD FOR PLASMID ISOLATION USING MICROTITER FILTER PLATES Analytical Biochemistry. ,vol. 230, pp. 130- 134 ,(1995) , 10.1006/ABIO.1995.1447
N.D. Sinha, J. Biernat, H. Köster, β-Cyanoethyl N,N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized oligonucleotides Tetrahedron Letters. ,vol. 24, pp. 5843- 5846 ,(1983) , 10.1016/S0040-4039(00)94216-3
T. Huth-Fehre, J. N. Gosine, K. J. Wu, C. H. Becker, Matrix-assisted laser desorption mass spectrometry of oligodeoxythmidylic acids Rapid Communications in Mass Spectrometry. ,vol. 6, pp. 209- 213 ,(1992) , 10.1002/RCM.1290060312