Analysis of the FGFR spatiotemporal expression pattern within the chicken scleral ossicle system.

摘要: Fibroblast Growth Factors (FGFs) play several important roles during organ morphogenesis and act as multi-functional growth factors that bind to their membrane bound receptors (FGFRs) activate further downstream signalling pathways. Several studies have investigated the function expression of FGF/FGFRs in endochondral bone development, however, we know little about role development neural crest derived intramembranous bones. Here, investigate 'b' c' isoforms FGFRs 1-3 scleral ossicles, a ring bones chicken eye. These are induced by conjunctival papillae. We identified both 'c' FGFRs1-3 phase 1 ossicle when papillae takes place. In contrast, 2, skeletal condensations mesenchyme, all were downregulated. This data shows for first time presence sclera, thus implicating FGFs pathway potentially involved development.