Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling.

摘要: Abstract Background Nuclear reprogramming with pluripotency factors enables somatic cells to gain the properties of embryonic stem cells. Mitochondrial resetting and metabolic are suggested be key early events in induction human skin fibroblasts induced pluripotent (iPSCs). Scope review We recent advances study molecular basis for mitochondrial regulation formation iPSCs. In particular, progress using iPSCs disease modeling was discussed. Major conclusions rely on glycolysis rather than oxidative phosphorylation as a major supply energy. thus play crucial roles process generation from General significance Neurons, myocytes, cardiomyocytes containing abundant mitochondria body, which can differentiated or trans-differentiated fibroblasts. Generating these derived patients diseases by trans-differentiation cell-specific transcription will provide valuable insights into role DNA heteroplasmy serves novel platform screening drugs treat diseases.