Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer.
作者： Santanu Dasgupta , Mohammad Obaidul Hoque , Sunil Upadhyay , David Sidransky
DOI: 10.1158/0008-5472.CAN-07-5532
关键词:
摘要: Mitochondria-encoded Cytochrome B (CYTB) gene mutations were reported in different cancers, but the effect of these on cellular metabolism and growth is unknown. In a murine xenograft human model bladder cancer, we show functional overexpression 21-bp deletion mutation (mt) CYTB. Overexpression mtCYTB generated increased reactive oxygen species (ROS) accompanied by consumption lactate production. MtCYTB induced significant tumor vitro vivo triggering rapid cell cycle progression through up-regulation nuclear factor-kappa B2 signaling pathway. Tumor-generated ROS lysis normal splenocytes. Thus, present physiologic evidence for role bona fide mitochondrial cancer.
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