Univariate and bivariate admixture analyses of serum glucose and glycated hemoglobin distributions in a Jerusalem population sample.

摘要: Univariate and bivariate analyses of fasting glucose glycated hemoglobin (HbA1c) levels 2 hours after an oral load test were performed in a random sample the Jewish population Jerusalem, aged 25-64 years. Using ln-transformed data, we found that mixture two distributions fits data significantly better than single distribution age groups 25-44 45-64 The results indicate 1.1% subjects 3.7% without known diabetes come from upper with mean values 154 mg/dl 224 mg/dl, respectively. Estimates analysis additional 2.1% younger 3.8% older belong to minor high value. frequency HbA1c is also bimodal all groups. Yet bimodality indicates only 0.1% 2.3% groups, respectively, 13.0-15.7%, compared 5.0% 5.3% for main distributions. levels, specificity rates are consistently greater 99%, whereas sensitivity vary age. use cutoff points suggested by National Diabetes Data Group (140 level 200 test) lower rate minimal improvement among subjects. A log-normal fitted 2-hour larger proportion (6.3%) belonging those obtained when variable used. this combined score shows low rate. No similar separating "normal" "abnormal" achieved variables. Admixture demonstrated. Bivariate these does not, however, provide discrimination putatively abnormal univariate analysis.